PE-22-28
No single human route established in this referenceAnimal / laboratory reference
Research reference
Animal / laboratory study
PE-22-28 shortened-spadin experiments
Short animal exposures, including a four-day experiment
Four-day mouse endpoints; action-duration experiments up to about 23 hours
Shortened spadin analogs, Frontiers in Pharmacology (2017) ↗When results may show
PE-22-28
Evidence gap- When change was measured
- Mouse behavior and neurogenesis are not a four-day human mood-response promise. Action duration is not a validated human dosing interval.
- When to assess
- Four-day mouse endpoints; action-duration experiments up to about 23 hours
- Conditions and limitations
- Channel/cell assays and mouse behavioral models. No human starting amount, course length, cycling, mixing volume or time-to-result is established by this experiment.
- When to stop
- The measured study window is not a validated personal quit rule. Do not increase or prolong exposure because an expected result is absent; severe or persistent reactions need prompt clinical review.
Research timing is descriptive, not a promise or personal instruction. A severe or persistent reaction needs prompt clinical review. This is not medical advice.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.00× single dose
- Time to steady state
- 5hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- Shortened spadin analogs, Frontiers in Pharmacology (2017)No human starting amount, course length, cycling, mixing volume or time-to-result is established by this experiment.