Dihexa
Also called PNB-0408
No single human route established in this referenceEvidence gap
Research reference
Evidence gap
Dihexa mechanism-paper retraction
No supported human starter or course
No established human outcome window
JPET retraction notice (2025)—not efficacy evidence ↗When results may show
Dihexa
Evidence gap- When change was measured
- The retracted HGF/c-Met paper cannot be used to promise memory benefit or establish a protocol. This source is a retraction notice, not supporting efficacy evidence.
- When to assess
- No established human outcome window
- Conditions and limitations
- The cited 2014 cell/animal mechanism paper was retracted in April 2025. No source-backed human amount, mixing plan or course was located. Do not substitute a related prodrug's human study or reuse the withdrawn mechanism findings.
- When to stop
- The measured study window is not a validated personal quit rule. Do not increase or prolong exposure because an expected result is absent; severe or persistent reactions need prompt clinical review.
Research timing is descriptive, not a promise or personal instruction. A severe or persistent reaction needs prompt clinical review. This is not medical advice.
Modelled level — every day
1× is the peak after a single dose.
- Steady-state peak
- 1.14× single dose
- Time to steady state
- 40hours
- Administrations
- 7/ week
Read off the modelled curve, not an even-interval formula
About five half-lives
Where these numbers come from
- JPET retraction notice (2025)—not efficacy evidenceNo source-backed human amount, mixing plan or course was located. Do not substitute a related prodrug's human study or reuse the withdrawn mechanism findings.